Acting's a tough business. If you're lucky enough to get a good role -- and perhaps find fame in it -- you have to keep up appearances at all times. Or else you might find yourself in the same spot as Isaiah Washington, who was out of job despite multiple apologies. What's he doing now?
Jorja Fox & George Eads
Roles: Sarah Sidle and Nicholas Stokes
Fox and Eads reportedly were fired from the show because they failed to show up on time in what appeared to be a bid for more money.
The now-famous comedian had a small role on the sitcom. One day, when he went to work, he reportedly couldn't find any parts for him. That's how he learned he'd been fired.
Role: Megan Donner
After 10 episodes, Delaney was written out of the popular crime show, reportedly because of a lack of chemistry with a star.
Role: Aunt Viv
Hubert-Whitten played Aunt Viv for the first three seasons of the sitcom, and she didn't return after having a child. Did creative differences with the lead character play a role?
Role: Becky Conner
Goranson played Roseanne's daughter until she left for college, but she came back, taking over the role for the most part in the eighth season.
Role: Taylor McBride
Tylo left a soap opera to take the role on "Melrose Place," then she got pregnant, and then she was fired. She sued.
Role: Harriette Winslow
Winslow, played the matriarch, had great chemistry with her screen husband. But she quit during the final season.
O'Donnell seemed to enjoy the back-and-forth on the daytime talk show, but at one point it escalated into an argument with another co-host. She left. She was turned down for another gig. She also recently had a health scare.
Character: Adam Newman
Engen, who played the son of Victor Newman on the show, quit last year over creative differences. Did he dislike a change in his character's sexual orientation?
Character: Weekend Update host
The comedian took over the job from this "SNL" alum, but he didn't get to pass it on to his successor because he was fired. Was it because he wasn't funny enough?
Role: Talk show host
In what likely is one of the messiest cast changes in talk show history, the old host took over "The Tonight Show" about a year after it was handed to O'Brien. How much did it cost NBC?